{"id":3387,"date":"2015-10-16T10:29:31","date_gmt":"2015-10-16T14:29:31","guid":{"rendered":"https:\/\/cells.wpengine.com\/?p=3387&#038;lang=fr"},"modified":"2015-10-16T10:29:31","modified_gmt":"2015-10-16T14:29:31","slug":"a-closer-look-at-hla-matching","status":"publish","type":"post","link":"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/","title":{"rendered":"A Closer Look at HLA Matching"},"content":{"rendered":"<p class=\"lead\">Unlike those of bone marrow and peripheral blood stem cells, cord blood stem cell transplants do not require an exact HLA match. This is because cord blood stem cells are more primitive and adaptable cells.<\/p>\n<p>What this means is that it is easier and faster to find a suitable donor for a cord blood transplant \u2013 in fact, there\u2019s a one in four chance of a perfect match between siblings and even the possibility of a match with extended family members.<\/p>\n<p>But let\u2019s back up a bit.<\/p>\n<h3>HLA Explained<\/h3>\n<p>Human leukocyte antigens (HLA) are proteins or markers that are located on the surface of most cells and tissues in the body. HLA differ from person to person. Every person has specific HLA markers that recognize which cells belong in the body. Some antigens appear more commonly in certain populations and ethnic groups.<\/p>\n<h3>The Importance of a Match<\/h3>\n<p>Half of a person\u2019s HLA markers are inherited from their mother, and the other half from their father. When two people share the same HLA, they are referred to as a \u201cfull match\u201d. Their tissues are immunologically compatible with each other.<\/p>\n<p>The best transplant outcome is reached when a patient\u2019s HLA and the donor\u2019s HLA closely match. According to\u00a0<a href=\"https:\/\/bethematch.org\/\">bethematch.org<\/a>, a close HLA match could mean:<\/p>\n<ul>\n<li>Increased likelihood of a successful transplant<\/li>\n<li>Improved engraftment rate (when the donated cells start to grow and develop new blood cells within the patient).<\/li>\n<li>Reduced risk of complications following the transplant \u2013 especially graft-versus-host disease (GVHD), a potentially serious complication.<\/li>\n<\/ul>\n<h3>HLA Typing<\/h3>\n<p>HLA typing is used as a tool to identify the HLA type, which is then used to match patients and donors for bone marrow, peripheral blood and cord blood stem cells.<\/p>\n<p>There are many groups of HLA, but three groups that are typically used for matching. Within each group, there are many different specific HLA proteins:<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" class=\"aligncenter  wp-image-1090\" src=\"https:\/\/cellsforlife.com\/wp-content\/uploads\/2013\/11\/HLAGroup.png\" alt=\"HLAGroup\" width=\"630\" height=\"241\" \/><\/p>\n<p>Here\u2019s a specific demonstration. Mary and John (shown below) each have two sets of three HLA. If John and Mary had a baby, the child would inherit a set of three HLA from each parent. This is one example of four possible combinations that the child could inherit from its parent:<\/p>\n<p><img loading=\"lazy\" class=\"aligncenter size-full wp-image-1091\" src=\"https:\/\/cellsforlife.com\/wp-content\/uploads\/2013\/11\/HLAexample.png\" alt=\"HLAexample\" width=\"900\" height=\"651\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>There are thousands of different combinations of possible HLA tissue types, which can make it difficult to find an exact match. As mentioned above, cord blood stem cells have the added benefit of not requiring an exact HLA antigen match between the donor and the recipient.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Unlike those of bone marrow and peripheral blood stem cells, cord blood stem cell transplants do not require an exact HLA match. This is because cord blood stem cells are more primitive and adaptable cells. What this means is that it is easier and faster to find a suitable donor for a cord blood transplant [&hellip;]<\/p>\n","protected":false},"author":22,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":""},"categories":[118],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v17.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A Closer Look at HLA Matching - Cells For Life<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Closer Look at HLA Matching - Cells For Life\" \/>\n<meta property=\"og:description\" content=\"Unlike those of bone marrow and peripheral blood stem cells, cord blood stem cell transplants do not require an exact HLA match. This is because cord blood stem cells are more primitive and adaptable cells. What this means is that it is easier and faster to find a suitable donor for a cord blood transplant [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/\" \/>\n<meta property=\"og:site_name\" content=\"Cells For Life\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CellsforLife\" \/>\n<meta property=\"article:published_time\" content=\"2015-10-16T14:29:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cellsforlife.com\/wp-content\/uploads\/2013\/11\/HLAGroup.png\" \/>\n<meta name=\"twitter:card\" content=\"summary\" \/>\n<meta name=\"twitter:creator\" content=\"@CellsForLife\" \/>\n<meta name=\"twitter:site\" content=\"@CellsForLife\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Faisal Muhammad\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture est.\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/cellsforlife.com\/#website\",\"url\":\"https:\/\/cellsforlife.com\/\",\"name\":\"Cells For Life\",\"description\":\"Cord Blood Bank\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/cellsforlife.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/#primaryimage\",\"inLanguage\":\"fr-FR\",\"url\":\"https:\/\/cellsforlife.com\/wp-content\/uploads\/2013\/11\/HLAGroup.png\",\"contentUrl\":\"https:\/\/cellsforlife.com\/wp-content\/uploads\/2013\/11\/HLAGroup.png\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/#webpage\",\"url\":\"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/\",\"name\":\"A Closer Look at HLA Matching - Cells For Life\",\"isPartOf\":{\"@id\":\"https:\/\/cellsforlife.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/#primaryimage\"},\"datePublished\":\"2015-10-16T14:29:31+00:00\",\"dateModified\":\"2015-10-16T14:29:31+00:00\",\"author\":{\"@id\":\"https:\/\/cellsforlife.com\/#\/schema\/person\/3fb2898bb3c462532105953732954056\"},\"breadcrumb\":{\"@id\":\"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/cellsforlife.com\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"A Closer Look at HLA Matching\"}]},{\"@type\":\"Person\",\"@id\":\"https:\/\/cellsforlife.com\/#\/schema\/person\/3fb2898bb3c462532105953732954056\",\"name\":\"Faisal Muhammad\",\"image\":{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/cellsforlife.com\/#personlogo\",\"inLanguage\":\"fr-FR\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/aadb2b2c84499bd5e4521c9e457f35f7?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/aadb2b2c84499bd5e4521c9e457f35f7?s=96&d=mm&r=g\",\"caption\":\"Faisal Muhammad\"},\"url\":\"https:\/\/cellsforlife.com\/fr\/author\/faisal\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A Closer Look at HLA Matching - Cells For Life","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/","og_locale":"fr_FR","og_type":"article","og_title":"A Closer Look at HLA Matching - Cells For Life","og_description":"Unlike those of bone marrow and peripheral blood stem cells, cord blood stem cell transplants do not require an exact HLA match. This is because cord blood stem cells are more primitive and adaptable cells. What this means is that it is easier and faster to find a suitable donor for a cord blood transplant [&hellip;]","og_url":"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/","og_site_name":"Cells For Life","article_publisher":"https:\/\/www.facebook.com\/CellsforLife","article_published_time":"2015-10-16T14:29:31+00:00","og_image":[{"url":"https:\/\/cellsforlife.com\/wp-content\/uploads\/2013\/11\/HLAGroup.png"}],"twitter_card":"summary","twitter_creator":"@CellsForLife","twitter_site":"@CellsForLife","twitter_misc":{"\u00c9crit par":"Faisal Muhammad","Dur\u00e9e de lecture est.":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebSite","@id":"https:\/\/cellsforlife.com\/#website","url":"https:\/\/cellsforlife.com\/","name":"Cells For Life","description":"Cord Blood Bank","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cellsforlife.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"fr-FR"},{"@type":"ImageObject","@id":"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/#primaryimage","inLanguage":"fr-FR","url":"https:\/\/cellsforlife.com\/wp-content\/uploads\/2013\/11\/HLAGroup.png","contentUrl":"https:\/\/cellsforlife.com\/wp-content\/uploads\/2013\/11\/HLAGroup.png"},{"@type":"WebPage","@id":"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/#webpage","url":"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/","name":"A Closer Look at HLA Matching - Cells For Life","isPartOf":{"@id":"https:\/\/cellsforlife.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/#primaryimage"},"datePublished":"2015-10-16T14:29:31+00:00","dateModified":"2015-10-16T14:29:31+00:00","author":{"@id":"https:\/\/cellsforlife.com\/#\/schema\/person\/3fb2898bb3c462532105953732954056"},"breadcrumb":{"@id":"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/cellsforlife.com\/fr\/a-closer-look-at-hla-matching\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/cellsforlife.com\/fr\/"},{"@type":"ListItem","position":2,"name":"A Closer Look at HLA Matching"}]},{"@type":"Person","@id":"https:\/\/cellsforlife.com\/#\/schema\/person\/3fb2898bb3c462532105953732954056","name":"Faisal Muhammad","image":{"@type":"ImageObject","@id":"https:\/\/cellsforlife.com\/#personlogo","inLanguage":"fr-FR","url":"https:\/\/secure.gravatar.com\/avatar\/aadb2b2c84499bd5e4521c9e457f35f7?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/aadb2b2c84499bd5e4521c9e457f35f7?s=96&d=mm&r=g","caption":"Faisal Muhammad"},"url":"https:\/\/cellsforlife.com\/fr\/author\/faisal\/"}]}},"_links":{"self":[{"href":"https:\/\/cellsforlife.com\/fr\/wp-json\/wp\/v2\/posts\/3387"}],"collection":[{"href":"https:\/\/cellsforlife.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cellsforlife.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cellsforlife.com\/fr\/wp-json\/wp\/v2\/users\/22"}],"replies":[{"embeddable":true,"href":"https:\/\/cellsforlife.com\/fr\/wp-json\/wp\/v2\/comments?post=3387"}],"version-history":[{"count":0,"href":"https:\/\/cellsforlife.com\/fr\/wp-json\/wp\/v2\/posts\/3387\/revisions"}],"wp:attachment":[{"href":"https:\/\/cellsforlife.com\/fr\/wp-json\/wp\/v2\/media?parent=3387"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cellsforlife.com\/fr\/wp-json\/wp\/v2\/categories?post=3387"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cellsforlife.com\/fr\/wp-json\/wp\/v2\/tags?post=3387"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}